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Fatigue Signaling

Meaning

Fatigue Signaling describes the complex, multi-systemic cascade of biochemical and neurological messages that communicate a state of reduced physiological capacity or systemic exhaustion to the central nervous system. This signaling is a protective, adaptive response, involving the interplay of peripheral metabolic changes, immune mediators, and central neuroendocrine modulation. Key hormonal and inflammatory markers are crucial for modulating the subjective perception and objective manifestation of profound, unresolving fatigue.