A multidisciplinary clinical approach dedicated to the objective assessment, root cause identification, and strategic mitigation of persistent physical or mental exhaustion that compromises performance and quality of life. This science integrates endocrinology, neurophysiology, and psychoneuroimmunology to address fatigue stemming from hormonal imbalances, chronic inflammation, or systemic overtraining. Effective management involves precision diagnostics and targeted interventions tailored to the underlying physiological deficit.
Origin
The formal study of fatigue management evolved from sports medicine and occupational health, recognizing that fatigue is not merely a subjective state but a measurable physiological phenomenon with specific biomarkers. In the context of wellness, it has expanded to address chronic fatigue states often linked to HPA axis dysregulation or mitochondrial dysfunction. The current approach emphasizes a scientific, rather than purely symptomatic, resolution.
Mechanism
Fatigue often results from a dysregulation of the HPA axis, leading to aberrant cortisol patterns, or from insufficient energy production due to mitochondrial impairment. Chronic overtraining or psychological stress can deplete neurotransmitter reserves and increase systemic inflammation, signaled by elevated cytokines. Management protocols aim to restore hormonal balance, optimize sleep architecture, and enhance cellular energy pathways to improve physiological resilience.
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