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Fat Storage Loop

Meaning

The Fat Storage Loop is the complex, cyclical interplay of hormonal signals and metabolic pathways that preferentially directs and locks energy substrates toward adipose tissue accumulation, often actively resisting efforts to mobilize and oxidize the stored fat reserves. This loop is primarily driven and reinforced by chronic energy surplus combined with systemic insulin resistance, creating a self-perpetuating cycle of persistent fat deposition. Understanding and breaking this loop is clinically vital for effectively addressing persistent weight management challenges and pervasive metabolic dysfunction.