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Fat Oxidation Pathway

Meaning

The Fat Oxidation Pathway, clinically known as beta-oxidation, is the catabolic metabolic process in which fatty acid molecules are broken down in the mitochondria to generate acetyl-CoA, which subsequently enters the Krebs cycle for energy production (ATP). This pathway is central to energy homeostasis, especially during fasting states or prolonged physical activity, and is significantly regulated by key hormones like insulin and glucagon. Efficient fat oxidation is crucial for body composition and metabolic flexibility, supporting sustained energy output.