What is the Origin of Fat Mass Regulation?

The concept stems from early physiological studies recognizing adipose tissue as an active endocrine organ, not just a passive energy store. The discovery of adipokines, such as leptin and adiponectin, cemented the understanding that fat mass is actively regulated by a feedback loop, giving rise to the term 'regulation' rather than simple accumulation.

What is the Mechanism of Fat Mass Regulation?

Regulation is orchestrated by a central neuroendocrine loop involving the hypothalamus and peripheral hormones released from adipose tissue, the pancreas, and the gut. Leptin signals satiety and energy status to the brain, while insulin controls glucose uptake and lipogenesis in adipocytes. Thyroid hormones and cortisol also modulate basal metabolic rate and lipolysis, collectively determining the dynamic equilibrium of fat mass.

Fat Mass Regulation ∞ Area

Fat Mass Regulation

Meaning

The complex, homeostatic control system governing the synthesis, storage, and mobilization of adipose tissue throughout the body. This process is fundamentally dictated by a sophisticated interplay of metabolic and endocrine signals, not merely caloric intake. Effective regulation ensures appropriate energy reserves while preventing excessive or ectopic fat accumulation, which is linked to metabolic dysfunction. It is a critical aspect of metabolic health and longevity.

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