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FADS Gene Polymorphisms

Meaning

FADS Gene Polymorphisms refer to common genetic variations, specifically Single Nucleotide Polymorphisms, found within the Fatty Acid Desaturase (FADS) gene cluster, which includes the FADS1 and FADS2 genes. These polymorphisms influence the efficiency of enzymes that are critical for synthesizing long-chain polyunsaturated fatty acids, such as EPA and DHA, from dietary precursors. These genetic variants are clinically significant as they profoundly impact an individual’s inflammatory status, lipid profile, and overall metabolic disease risk.