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Extraglandular Aromatization

Meaning

Extraglandular Aromatization is the biochemical process where androgens, primarily testosterone and androstenedione, are converted into estrogens outside of the primary endocrine glands, such as the ovaries and testes. This critical conversion is catalyzed by the enzyme aromatase, which is highly expressed in peripheral tissues, notably adipose (fat) tissue, muscle, and the liver. Clinically, this process is a significant source of circulating estrogen in postmenopausal women and in men, directly influencing the hormonal milieu and metabolic health. Excess adipose tissue correlates directly with increased aromatase activity, which can lead to elevated estrogen levels and subsequent clinical sequelae.