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Extracellular Residence Time

Meaning

Extracellular Residence Time refers to the total duration a therapeutic molecule, such as a peptide or hormone, remains biologically active within the interstitial fluid and plasma compartments before being metabolized or cleared. This pharmacokinetic parameter is a critical determinant of a compound’s systemic availability and its capacity to interact with cell surface receptors over time. A longer residence time generally translates to a prolonged biological effect, potentially allowing for less frequent dosing. Clinicians prioritize optimizing this time to ensure continuous, stable signaling for sustained therapeutic outcomes.