Extracellular Matrix Health refers to the optimal functional state of the complex network of macromolecules, including collagen, elastin, and proteoglycans, that provides structural and biochemical support to surrounding cells. Maintaining its integrity is vital for proper tissue signaling.
Origin
This concept originates from histology and cell biology, recognizing the matrix as an active, signaling participant in tissue regulation rather than simply inert scaffolding material for cells.
Mechanism
Health is maintained through a balanced synthesis and degradation of matrix components, governed by the actions of various enzymes and cellular communication. Proper hydration and appropriate growth factor signaling dictate matrix composition and organizational structure.
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