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Extended Wakefulness Consequences

Meaning

Extended Wakefulness Consequences refers to the cascade of adverse physiological, metabolic, and cognitive effects that result from prolonged periods without adequate sleep, moving beyond simple fatigue to measurable systemic disruption. Clinically, this state is associated with acute endocrine imbalance, including elevated evening cortisol levels, decreased insulin sensitivity, and impaired glucose tolerance. These consequences represent a failure of homeostatic recovery, impacting everything from immune function to emotional regulation.