What is the Origin of Extended Healthspan Extension?

This term arises from the field of geroscience, distinguishing between simple longevity and the more valuable metric of "healthspan." It reflects a translational shift in focus toward maintaining physiological reserve capacity across systems. The concept integrates insights from cellular senescence, proteostasis, and epigenetic regulation as targets for intervention.

What is the Mechanism of Extended Healthspan Extension?

Protocols supporting this extension often target senescent cell clearance, modulate nutrient sensing pathways like IGF-1 signaling, and enhance DNA damage response mechanisms through supportive therapies. By reducing the cumulative burden of molecular damage, the overall rate of physiological decline is theoretically slowed across multiple axes. Successful implementation aims to compress the period of morbidity late in life, preserving functional autonomy.

Extended Healthspan Extension ∞ Area

Extended Healthspan Extension

Meaning

A clinical objective focused on increasing the duration an individual experiences full physiological function and freedom from age-related morbidity, rather than merely extending chronological lifespan. This requires intervening against the hallmarks of aging at the molecular and systemic levels concurrently. The primary aim is maximizing years lived in robust, high-functioning health.