What is the Origin of Exogenous Signal Timing?

Derived from 'Exogenous' (originating outside the organism), 'Signal' (a communication molecule), and 'Timing' (the precise moment of application). It is a core principle in chronopharmacology and nutritional chronobiology.

What is the Mechanism of Exogenous Signal Timing?

The efficacy relies on the principle of receptor upregulation and hormonal pulsatility, where administering an exogenous substance during a period of maximal receptor density or when a counter-regulatory hormone is naturally low yields a superior net effect. For example, administering a growth hormone secretagogue at the onset of sleep aligns with the natural GH pulse, maximizing the physiological benefit.

Exogenous Signal Timing ∞ Area

Exogenous Signal Timing

Meaning

The strategic application of external compounds, such as nutrients, peptides, or pharmaceutical agents, at specific, deliberate points within the body’s endogenous circadian or ultradian hormonal cycles. This timing aims to amplify a desired physiological response or mitigate an undesirable effect.

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