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Exogenous Ligand Titration

Meaning

Exogenous Ligand Titration is the clinical process of systematically adjusting the administered dosage of an external substance—a hormone, hormone analog, or a molecule that binds to an endocrine receptor—to achieve a specific, targeted physiological or biochemical concentration within the patient’s circulatory system or tissue. This precise adjustment, or titration, is guided by frequent monitoring of circulating hormone levels and downstream biomarkers to ensure the desired therapeutic effect is achieved without inducing adverse supra-physiological or sub-therapeutic effects. This careful balancing act is essential for personalized hormone replacement therapy, optimizing the patient’s endocrine homeostasis.