What is the Origin of Exogenous Ketone Supplementation?

The term combines "exogenous," meaning originating outside the organism, with "ketone supplementation," the act of adding ketone bodies to the diet. This practice emerged from research into the ketogenic diet's therapeutic applications for neurological disorders. It represents a pharmacological approach to mimic the metabolic state achieved through fasting or carbohydrate restriction.

What is the Mechanism of Exogenous Ketone Supplementation?

Upon ingestion, exogenous ketones are absorbed in the gut and rapidly metabolized to increase the plasma concentration of BHB. BHB then crosses the blood-brain barrier and is utilized by neurons and other tissues for ATP production. This bypasses the liver's natural process of ketogenesis, offering an immediate source of "deep work fuel" and exerting signaling effects, such as inhibiting histone deacetylases, which can modulate gene expression and reduce inflammation.

Exogenous Ketone Supplementation

Meaning

Exogenous ketone supplementation involves the ingestion of ketone bodies, typically as salts or esters, to elevate the circulating concentration of beta-hydroxybutyrate (BHB) in the blood without requiring a state of nutritional ketosis. This strategy is employed to rapidly induce a state of mild ketosis, providing an alternative fuel source for the brain and muscles. It is often used clinically to explore the neuroprotective and metabolic benefits of ketones independent of dietary restriction.