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Exogenous Hormone Response Variation

Meaning

Exogenous Hormone Response Variation describes the clinically observed phenomenon where individuals exhibit significantly different physiological and biochemical reactions to the administration of identical doses and forms of externally supplied (exogenous) hormones. This variability in therapeutic outcome necessitates a highly personalized approach to hormone replacement therapy. The differences can manifest in terms of changes in circulating hormone levels, symptomatic relief, side effect profiles, and overall therapeutic efficacy. Recognizing and managing this variation is a hallmark of precision endocrinology and individualized treatment planning.