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Exogenous Hormone Clearance

Meaning

Exogenous Hormone Clearance defines the physiological process by which the body metabolizes and eliminates hormones that originate from external sources, such as hormone replacement therapy, oral contraceptives, or environmental endocrine-disrupting chemicals. This process is highly dependent on the efficiency of the hepatic detoxification pathways and renal excretion mechanisms. Effective clearance is essential for preventing the accumulation of active or toxic hormone compounds, thereby minimizing the potential for side effects and maintaining a stable hormonal milieu. Impaired clearance can significantly amplify the systemic hormone burden, contributing to functional excess.