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Exogenous Hormone Bioavailability

Meaning

Exogenous hormone bioavailability quantifies the fraction of an administered, non-naturally produced hormone that reaches the systemic circulation and is subsequently available to exert its intended biological effect on target tissues. This metric is fundamentally important in clinical endocrinology, particularly for Hormone Replacement Therapy (HRT) or Testosterone Replacement Therapy (TRT) dosing. The route of administration, whether oral, transdermal, injectable, or pellet, profoundly influences this value, directly impacting both therapeutic efficacy and overall safety profiles.