Question 1

What is the Meaning of Exogenous GH?

Accepted Answer

Exogenous GH refers to growth hormone administered externally, distinct from pituitary-produced somatotropin. This synthetic form, recombinant human growth hormone (rhGH), is manufactured biotechnologically to replicate the endogenous hormone's structure. Its primary purpose is to supplement or replace insufficient natural GH levels in the body.

Question 2

What is the Context of Exogenous GH?

Accepted Answer

Within human endocrinology, endogenous growth hormone, secreted by the anterior pituitary, regulates growth, metabolism, and body composition. Exogenous GH operates within this hormonal environment, interacting with native signaling pathways. It becomes relevant when the pituitary fails to produce adequate somatotropin.

Question 3

What is the Significance of Exogenous GH?

Accepted Answer

The clinical importance of exogenous GH addresses growth hormone deficiency in children and adults. For pediatric cases, it facilitates linear growth and bone development. In adults, administration improves body composition, reducing adiposity, increasing lean muscle mass, positively influencing lipid profiles, and supporting metabolic health.

Question 4

What is the Mechanism of Exogenous GH?

Accepted Answer

Exogenous GH acts by binding to specific growth hormone receptors on target cells. This initiates a signaling cascade, primarily stimulating the liver to produce insulin-like growth factor-1 (IGF-1), mediating many of GH's anabolic and growth-promoting effects. Direct actions on adipose and muscle tissues also contribute to systemic impact.

Question 5

What is the Application of Exogenous GH?

Accepted Answer

Clinically, exogenous GH is administered via subcutaneous injection, typically once daily, for indications like pediatric and adult growth hormone deficiency, Turner syndrome, and chronic kidney disease. Protocols are individualized, with dosing titrated based on patient age, IGF-1 levels, and clinical response.

Question 6

What is the Metric of Exogenous GH?

Accepted Answer

Efficacy and safety of exogenous GH therapy are monitored through clinical and biochemical assessments. Serum IGF-1 levels serve as a primary biomarker. In children, growth velocity and height standard deviation scores are critical. For adults, assessments include body composition, bone mineral density, and metabolic parameters.

Question 7

What is the Risk of Exogenous GH?

Accepted Answer

While generally safe under medical supervision, exogenous GH therapy carries potential risks. Common adverse events include fluid retention, peripheral edema, and joint pain. Metabolic alterations like insulin resistance and impaired glucose tolerance may occur, requiring blood sugar monitoring. Rare risks include benign intracranial hypertension, emphasizing thorough patient selection and ongoing clinical evaluation.

Exogenous GH

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

How Does CJC-1295 Influence Growth Hormone Pulsatility Compared to Exogenous GH?