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Exogenous Androgen Cessation

Meaning

Exogenous Androgen Cessation is the clinical process of discontinuing the administration of externally supplied androgen hormones, such as testosterone, leading to a necessary period of physiological adjustment. This phase is characterized by a temporary, often significant, suppression of the body’s endogenous hormone production due to the negative feedback exerted by the external hormones on the Hypothalamic-Pituitary-Gonadal (HPG) axis. Careful clinical management is essential during cessation to mitigate symptoms of transient hypogonadism and facilitate the restoration of natural hormone synthesis. This is a critical transition in hormonal health.