These are the diverse array of molecular, hormonal, and neural messengers generated by the body in direct response to physical exertion. They include myokines released from muscle, adipokines from fat tissue, and catecholamines from the adrenal medulla, all of which coordinate systemic adaptation. These signals drive beneficial changes in metabolism, cardiovascular function, and tissue remodeling.
Origin
The concept is rooted in the field of exercise physiology, which studies the acute and chronic responses of the body to physical activity. The term signals emphasizes the communication role of these released molecules, translating mechanical and metabolic stress into systemic biological instruction. Understanding these signals is central to prescribing exercise for health and hormonal optimization.
Mechanism
During exercise, muscle contraction releases myokines that act locally and systemically, influencing insulin sensitivity and fat metabolism. Concurrently, the sympathetic nervous system releases catecholamines to increase heart rate and mobilize energy substrates. These coordinated signals act on target organs, such as the liver and adipose tissue, to promote metabolic flexibility and enhance mitochondrial biogenesis, which is crucial for hormonal health.
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