What is the Origin of Exercise Neurogenesis?

This concept arose from modern behavioral neuroscience, specifically challenging earlier dogma by demonstrating that adult mammalian brains retain plasticity in neurogenesis capacity. Exercise was identified as a potent, non-pharmacological modulator of this process, often mediated by systemic factors released into circulation during activity.

What is the Mechanism of Exercise Neurogenesis?

Physical exertion triggers the systemic release of various growth factors, most notably Brain-Derived Neurotrophic Factor (BDNF), which acts directly on neural progenitor cells to promote their proliferation and subsequent differentiation. Furthermore, improved systemic hemodynamics enhances cerebral oxygenation and substrate delivery, creating a favorable microenvironment for neuronal survival and integration. Endocrine changes associated with exercise, such as optimized insulin sensitivity, also support the elevated metabolic demands of newly formed neurons.

Exercise Neurogenesis ∞ Area

Exercise Neurogenesis

Meaning

Exercise Neurogenesis describes the specific biological process wherein physical activity stimulates the birth and integration of new neurons, primarily within the hippocampal formation, a region vital for learning and declarative memory. This activity-dependent phenomenon is a crucial mechanism for maintaining cognitive function and plasticity throughout adult life. It represents a tangible, quantifiable biological link between physical exertion and beneficial brain structure modification.