What is the Origin of Exercise Induced Neurogenesis?

The term combines the physiological domain of exercise science with the neurobiological concept of neurogenesis, the creation of new neurons. It gained prominence with research demonstrating that physical activity, particularly aerobic exercise, is a potent non-pharmacological modulator of brain health. The discovery challenged the long-held dogma that the adult mammalian brain was incapable of generating new neurons.

What is the Mechanism of Exercise Induced Neurogenesis?

The primary mechanism involves the exercise-mediated release of neurotrophic factors, most notably Brain-Derived Neurotrophic Factor (BDNF), from both muscle tissue and the brain itself. BDNF acts on TrkB receptors in the hippocampus, promoting the survival, differentiation, and integration of newly born neurons into existing neural circuits. Furthermore, improved cerebral blood flow and reduced systemic inflammation contribute to a neurogenic environment.

Exercise Induced Neurogenesis

Meaning

Exercise Induced Neurogenesis is the physiological process by which physical activity stimulates the proliferation and differentiation of new neurons from neural stem cells, primarily within the hippocampus of the adult brain. This phenomenon represents a critical mechanism for improving cognitive function, enhancing memory, and increasing resilience against neurological decline. It links musculoskeletal exertion directly to structural brain plasticity.