What is the Origin of Exercise Induced Myokines?

The term combines "exercise-induced," indicating the trigger, with "myokine," derived from the Greek myo (muscle) and kine (movement or signal). This concept emerged in the early 2000s, revolutionizing endocrinology by establishing skeletal muscle as a vital endocrine organ. The discovery challenged the previous view of muscle as solely a locomotor and metabolic sink, highlighting its profound systemic regulatory role.

What is the Mechanism of Exercise Induced Myokines?

Mechanical and metabolic stress within the muscle cell during exercise stimulates the transcription and release of various myokines, such as Interleukin-6 (IL-6), Irisin, and BDNF. Once secreted, these peptides travel through the bloodstream to exert paracrine or endocrine effects on target tissues. Their function includes enhancing glucose uptake, promoting fat breakdown, improving insulin sensitivity, and supporting neurogenesis, thus linking muscular activity directly to systemic health and longevity.

Exercise Induced Myokines ∞ Area

Exercise Induced Myokines

Meaning

Exercise Induced Myokines are a class of small signaling peptides, or proteins, released by skeletal muscle fibers into the circulation following muscle contraction during physical activity. These molecules function as hormones, mediating cross-talk between muscle and other distant organs, including adipose tissue, liver, brain, and bone. They represent a key mechanism by which exercise exerts its systemic anti-inflammatory and metabolic benefits, transforming muscle into an active endocrine organ.