What is the Origin of Exercise and Neurogenesis?

This term emerged from experimental neurobiology in the late 20th century, challenging the long-held dogma that the adult mammalian brain could not generate new neurons. Early animal studies definitively demonstrated that voluntary running significantly increased cell proliferation in the dentate gyrus of the hippocampus. The concept is rooted in the field of exercise physiology intersecting with molecular neuroscience.

What is the Mechanism of Exercise and Neurogenesis?

The mechanism is multi-factorial, primarily mediated by the exercise-induced increase in systemic and cerebral concentrations of neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF). Physical activity also enhances cerebral blood flow, improving the delivery of oxygen and glucose to the progenitor cell niches. Furthermore, exercise modulates the inflammatory and oxidative stress environments, creating a more favorable milieu for the survival, differentiation, and integration of the newly formed neurons into existing hippocampal circuits, thereby enhancing learning and memory.

Exercise and Neurogenesis ∞ Area

Exercise and Neurogenesis

Meaning

Exercise and Neurogenesis describes the scientifically established link between voluntary physical activity and the process of neurogenesis, which is the formation of new functional neurons from progenitor cells, primarily occurring in the adult hippocampus. This physiological correlation highlights exercise as a potent non-pharmacological stimulus for enhancing brain plasticity and improving cognitive reserve. It is a cornerstone concept in lifestyle medicine for brain health and longevity.