A clinical objective focused on enhancing the core set of cognitive processes managed by the prefrontal cortex, including working memory, flexible thinking, inhibitory control, and goal-directed behavior. This strategy aims to improve the speed, efficiency, and robustness of the neural circuitry responsible for complex decision-making and sustained focus. Uprating this function is central to maximizing mental performance and adaptability.
Origin
The term synthesizes concepts from neuropsychology, cognitive enhancement research, and functional neurology, specifically addressing the hormonal and metabolic factors that influence frontal lobe activity. It moves the clinical focus from treating cognitive deficit to optimizing the existing capacity of the central nervous system.
Mechanism
This enhancement is achieved by modulating key neurohormones and neurotransmitters, such as dopamine, acetylcholine, and thyroid hormone, which are critical for prefrontal cortical signaling and neuronal plasticity. Interventions focus on improving cerebral blood flow, optimizing mitochondrial energy supply to neurons, and ensuring adequate synthesis of necessary neurochemicals. This integrated mechanism supports the structural and functional integrity required for complex cognitive execution.
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