Skip to main content

Executive Function Substrates

Meaning

Executive Function Substrates are the essential biochemical and energetic compounds required by the prefrontal cortex to perform complex cognitive processes, collectively known as executive functions. These critical processes include working memory, inhibitory control, cognitive flexibility, and goal-directed behavior. The primary substrates are glucose and oxygen, but the term also encompasses key neurotransmitter precursors, cofactors, and neuromodulatory hormones that facilitate efficient neural signaling. Optimal provision of these substrates is necessary for peak mental performance and sustained focus.