A quantifiable and standardized measurement derived from neurocognitive testing that assesses a person’s high-level cognitive skills, including working memory, cognitive flexibility, inhibitory control, and goal-directed behavior. This metric is a vital clinical indicator of frontal lobe integrity and the capacity for complex decision-making.
Origin
The concept is rooted in neuropsychology and clinical assessment, where a battery of standardized tests is used to objectively evaluate the integrity of the brain’s executive control systems. In the context of hormonal health, it is used to track the impact of endocrine interventions on cognitive performance.
Mechanism
Executive function is mediated by intricate neural networks involving the prefrontal cortex, which requires a substantial and consistent supply of cerebral energy, primarily ATP. The metric reflects the efficiency of neurotransmitter systems like dopamine and norepinephrine, which are themselves highly sensitive to fluctuations in systemic hormones such as thyroid and sex steroids, linking endocrine status directly to cognitive output.
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