Executive Function Degradation is the measurable decline in the higher-level cognitive processes controlled by the prefrontal cortex, including working memory, inhibitory control, and cognitive flexibility. Clinically, this manifests as reduced planning ability, increased impulsivity, and difficulty sustaining attention on complex tasks. This degradation is often a consequence of chronic stress, sleep deprivation, or neuro-endocrine imbalance.
Origin
The term is foundational to clinical neuropsychology, describing the impairment of the brain’s “CEO” functions. In the context of hormonal health, it specifically addresses how systemic factors, such as cortisol dysregulation or declining sex hormone levels, contribute to cognitive decline beyond normal aging.
Mechanism
Chronic exposure to elevated glucocorticoids, like cortisol, can induce structural changes in the prefrontal cortex and hippocampus, impairing synaptic plasticity and reducing neuronal density. Furthermore, inadequate deep sleep prevents the necessary metabolic clearance and consolidation of information, leading to an accumulated cognitive debt. This combination of neurotoxicity and insufficient recovery compromises the neural substrate required for robust executive control.
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