The neurochemical environment, particularly involving neurotransmitters and specific neurosteroids, that directly underpins higher-order cognitive processes such as planning, working memory, inhibitory control, and cognitive flexibility. Optimal executive function relies on the precise balance and availability of these signaling molecules within prefrontal cortical circuits. We look at the hormonal underpinnings of focus and decision-making.
Origin
This term merges cognitive neuroscience, which defines executive functions, with neuroendocrinology, recognizing that systemic hormones influence brain chemistry. It highlights that complex mental performance is directly tied to the body’s internal chemical milieu, not just neural activity alone.
Mechanism
Key mechanisms involve the modulation of dopamine signaling for motivation and reward, and norepinephrine for attentional focus, both of which are sensitive to systemic cortisol levels and sex hormone fluctuations. Thyroid hormones also play a permissive role in maintaining appropriate receptor density and signaling fidelity for these critical neurotransmitter systems, ensuring efficient cognitive throughput.
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