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Excitotoxicity Mitigation

Meaning

Excitotoxicity Mitigation refers to the clinical and biological strategies employed to reduce or prevent excitotoxicity, a pathological process where excessive or prolonged activation of excitatory amino acid receptors, particularly NMDA receptors by glutamate, leads to neuronal damage and death. Effective mitigation is a crucial neuroprotective goal in acute neurological events and chronic neurodegenerative conditions. This delicate balance is vital for maintaining neural network integrity and preventing cellular burnout.