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Excipient Immunomodulation

Meaning

Excipient immunomodulation describes the often-unintended or subtle influence that pharmacologically inactive ingredients, known as excipients, within a compounded pharmaceutical formulation can exert upon the host’s immune system. These effects can range from inducing minor local inflammatory reactions to causing more significant systemic changes in inflammatory pathways or triggering overt allergic responses. In the context of personalized hormonal therapies, selecting truly inert excipients is paramount to ensure therapeutic purity and avoid confounding immunological side effects that may complicate clinical outcomes.