The application of interventions and strategies for extending human healthspan and lifespan that are supported by rigorous, reproducible clinical trial data and mechanistic biological evidence, particularly within aging and endocrinology. It mandates moving beyond anecdotal claims to protocols validated by the highest tiers of scientific inquiry. This approach seeks to optimize the trajectory of biological decline.
Origin
This modern concept stems from the maturation of clinical epidemiology and molecular gerontology, demanding that longevity protocols meet the same evidentiary standards as established medical treatments. It represents a commitment to scientific rigor in the pursuit of extended vitality. The term emphasizes empirical validation over hypothesis alone.
Mechanism
The mechanism involves identifying and targeting fundamental aging pathways—such as senescence, nutrient sensing (like mTOR), or telomere attrition—with interventions proven through controlled studies to alter the rate of physiological deterioration. Successful application requires monitoring validated biomarkers of aging and healthspan, ensuring interventions yield tangible improvements in functional capacity.
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