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Eugonadal Hypogonadism

Meaning

Eugonadal hypogonadism describes a specific clinical state where an individual exhibits clear, symptomatic signs of hormone deficiency, characteristic of hypogonadism, yet their circulating total hormone levels fall within the statistically normal, or eugonadal, laboratory reference range. This paradoxical presentation suggests a functional impairment at the cellular or tissue level, rather than a primary failure of hormone production. It serves as a crucial reminder that relying solely on total hormone measurements can lead to missed diagnoses and undertreatment of symptomatic patients. A thorough clinical evaluation is therefore paramount.