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Estrogenome

Meaning

The Estrogenome represents the comprehensive network of genes, proteins, and metabolic pathways that collectively dictate an individual’s unique response to estrogen and its metabolites. This term extends beyond simple estrogen receptor binding to encompass the entire life cycle of estrogens, including their synthesis, transport, Phase I and Phase II metabolism, and downstream gene regulation. Understanding the Estrogenome involves analyzing genetic polymorphisms in key enzymes, such as CYP450s and UGTs, and receptor genes, which influence overall estrogenic exposure and effect. This personalized genetic map is crucial for predicting risk for hormone-sensitive conditions and optimizing exogenous hormone therapy.