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Estrogen Variability

Meaning

Estrogen Variability refers to the natural, often dramatic, fluctuations in the concentration of circulating estrogen hormones, particularly estradiol (E2), that occur throughout a woman’s reproductive lifespan and during transitional periods. This normal physiological pattern is most pronounced across the menstrual cycle, where levels rise and fall in a predictable, rhythmic fashion to orchestrate ovulation and endometrial development. Significant variability, especially the extreme flux observed during the perimenopausal transition, is strongly correlated with changes in mood, cognitive function, and increased emotional sensitivity to stress.