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Estrogen Replacement

Meaning

Estrogen Replacement is a therapeutic intervention involving the administration of estrogen to individuals experiencing a deficiency or loss of endogenous estrogen production, most commonly due to menopause, surgical removal of the ovaries, or primary ovarian insufficiency. The primary clinical goal is to mitigate moderate to severe vasomotor symptoms, genitourinary syndrome of menopause, and to protect against bone density loss. This therapy is a component of Hormone Replacement Therapy (HRT), requiring careful clinical consideration of individual risks and benefits, especially concerning cardiovascular and thrombotic health.