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Estrogen Receptors in Thyroid

Meaning

Estrogen Receptors (ERs) in the Thyroid refers to the confirmed presence of specific nuclear hormone receptors, primarily ER-alpha and ER-beta, within the cells of the thyroid gland. These receptors function as ligand-activated transcription factors, mediating the direct biological effects of circulating estrogen hormones on the thyroid tissue. Their expression suggests that estrogen is a crucial modulator of thyroid function, influencing cell proliferation, hormone synthesis, and potentially the differential prevalence of thyroid disorders between sexes. This finding underscores the profound cross-talk between the endocrine systems.