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Estrogen Receptor Activity

Meaning

Estrogen Receptor Activity describes the functional status and signaling capacity of the intracellular proteins that bind to the steroid hormone estrogen, mediating its diverse biological effects across numerous tissues. These receptors, primarily Estrogen Receptor alpha (ERα) and Estrogen Receptor beta (ERβ), act as ligand-activated transcription factors, modulating gene expression for processes like bone density maintenance, cardiovascular health, and neuroprotection. The activity is a measure of both the receptor’s concentration and its affinity for estrogen, which is crucial for understanding tissue-specific hormonal responses.