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Estrogen-Progestin Therapy (EPT)

Meaning

Estrogen-Progestin Therapy, or EPT, is a standard therapeutic approach used to alleviate the vasomotor and genitourinary symptoms associated with menopause in women who have an intact uterus. This regimen involves the co-administration of an estrogen compound, which targets symptoms like hot flashes and vaginal atrophy, alongside a progestin component. The inclusion of progestin is a critical safety measure specifically designed to mitigate the increased risk of endometrial hyperplasia and cancer caused by unopposed estrogenic stimulation of the uterine lining. It is a carefully balanced strategy for managing the endocrine transition of menopause.