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Estrogen-Progestin Therapy

Meaning

Estrogen-Progestin Therapy (EPT) is a specific, combined form of menopausal hormone therapy prescribed primarily for postmenopausal women who still possess an intact uterus. This therapeutic regimen integrates an estrogen compound to effectively manage debilitating vasomotor symptoms and prevent accelerated bone mineral loss, alongside a progestin compound to provide essential counter-regulation against estrogen’s effects on the uterine lining. The inclusion of the progestin component is a non-negotiable clinical necessity to mitigate the heightened risk of developing endometrial hyperplasia and subsequent carcinoma associated with unopposed estrogen exposure.