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Estrogen Progesterone Cadence

Meaning

Estrogen Progesterone Cadence describes the precise, cyclical, and rhythmic fluctuation of the primary female sex hormones, estradiol (a form of estrogen) and progesterone, throughout the menstrual cycle. This synchronized hormonal pattern is fundamental not only for reproductive health but also for maintaining the temporal organization of mood, cognition, bone density, and cardiovascular health across the lifespan. A healthy cadence is characterized by the distinct phase shifts: a proliferative phase dominated by estrogen followed by a secretory phase marked by progesterone. Disruptions in this rhythm, such as during perimenopause, can lead to widespread systemic symptoms due to loss of temporal hormonal signaling.