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Estrogen Neuroprotection

Meaning

Estrogen Neuroprotection refers to the diverse, beneficial effects of estrogen hormones, particularly 17β-estradiol, on the functional and structural integrity of the central nervous system, which serve to promote neuronal survival, enhance synaptic plasticity, and reduce the vulnerability to neurodegenerative processes. Estrogen actively modulates cerebral blood flow, acts as a potent endogenous antioxidant, and regulates the expression of key neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF). This protective effect is of significant clinical relevance for women, as the decline in endogenous estrogen levels during the menopausal transition can correlate with an increased risk of cognitive decline and heightened neuroinflammatory states. It is a critical, yet often underappreciated, component of lifelong brain health.