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Estrogen Neuroprotection Timelines

Meaning

This refers to the clinical and physiological understanding of how the timing of estrogen intervention, relative to the onset of menopause or hormonal decline, critically influences its ability to safeguard brain structure and cognitive function. Research suggests a ‘critical window’ or specific timeline during which estrogen therapy offers maximal neuroprotective benefits, particularly concerning neurodegenerative risk. The concept guides clinical decisions on hormone replacement therapy initiation for cognitive health.