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Estrogen Neuronal Integrity

Meaning

The essential role of estrogen hormones, particularly estradiol, in maintaining the structural integrity and functional health of neurons and glial support cells within the central nervous system. Estrogen acts as a potent, endogenous neuroprotectant, profoundly influencing synaptic density, dendritic arborization, and overall neuronal resilience against oxidative stress and excitotoxicity. The decline in circulating estrogen levels, such as during the menopausal transition, compromises this integrity, often leading to noticeable cognitive and emotional symptoms.