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Estrogen Nephroprotection

Meaning

Estrogen Nephroprotection describes the documented beneficial physiological effects of endogenous estrogen hormones, particularly estradiol, that serve to shield the renal system from various forms of damage. This protective action is critical in mitigating injury caused by common systemic insults, including chronic hypertension, diabetes-related vascular changes, and inflammation. This phenomenon largely explains the epidemiologically observed lower incidence of progressive chronic kidney disease in premenopausal women compared to their male counterparts. The preservation of robust kidney function is a vital component of long-term hormonal health and systemic longevity.