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Estrogen-Gut Microbiome Axis

Meaning

The Estrogen-Gut Microbiome Axis describes the bidirectional communication and influence between circulating estrogens and the microbial community residing within the human gut. This dynamic interaction impacts the synthesis, metabolism, and elimination of estrogens, directly affecting their bioavailability and biological activity throughout the body. A specific subset of gut bacteria, often referred to as the estrobolome, produces enzymes like beta-glucuronidase that regulate estrogen deconjugation and reabsorption.