What is the Origin of Estrogen Dominance Gut?

This term originates in clinical gynecology and endocrinology, where estrogen dominance is a recognized pattern, now linked directly to the "Gut" microbiome's role in steroid recirculation. The concept hinges on the enterohepatic circulation of estrogens, which is heavily influenced by the resident bacterial population.

What is the Mechanism of Estrogen Dominance Gut?

The critical mechanism involves bacterial enzymes, notably $beta$-glucuronidase, that cleave glucuronide conjugates of estrogen excreted via bile. By deconjugating these metabolites, the gut bacteria effectively return active estrogen into the systemic circulation, preventing its elimination. An overgrowth of these specific bacteria can therefore lead to a functional estrogen excess, even if adrenal or ovarian production remains constant.

Estrogen Dominance Gut ∞ Area

Estrogen Dominance Gut

Meaning

Estrogen Dominance Gut describes a state where the influence of estrogen relative to progesterone is disproportionately high, with the gut microbiota playing a key role in perpetuating this imbalance. This involves microbial actions that increase the bioavailability of circulating estrogens, thereby exacerbating estrogenic effects on target tissues. Recognizing this connection allows for targeted nutritional intervention to restore endocrine proportionality.