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Estrogen Deconjugation

Meaning

Estrogen Deconjugation is the biochemical process in which conjugated, inactive forms of estrogen are converted back into their biologically active, free-form state within the gastrointestinal tract. This process is mediated by the enzyme beta-glucuronidase, which is produced by certain gut bacteria. It is a critical, yet often overlooked, step in the enterohepatic circulation of estrogens, directly influencing the body’s total effective estrogen load. Clinically, an excessive rate of deconjugation can lead to the reabsorption of estrogens that were slated for excretion, potentially contributing to conditions of estrogen dominance or other hormone-sensitive issues.