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Estrogen Decline

Meaning

Estrogen Decline refers to the progressive and significant physiological reduction in the circulating levels of estrogen hormones, predominantly estradiol, which occurs naturally as women transition through perimenopause and into the postmenopausal phase. This profound endocrine shift results from the progressive depletion of ovarian follicles and the subsequent cessation of cyclic ovarian hormone production. The resultant hypoestrogenic state affects numerous body systems, manifesting as various climacteric symptoms and contributing to long-term health risks.