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Estrogen Balance

Meaning

Estrogen balance refers to the relative concentrations and activities of the three primary estrogens—estradiol ($text{E}2$), estrone ($text{E}1$), and estriol ($text{E}3$)—and their proportionate interaction with the estrogen receptor subtypes ($text{ER}alpha$ and $text{ER}beta$). Optimal balance ensures that estrogenic effects are appropriate for the target tissue and the individual’s life stage. Imbalance can drive proliferative or atrophic conditions.